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Journal of the National Cancer Institute Advance Access published online on June 17, 2009
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djp162
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© The Author 2009. Published by Oxford University Press.

EDITORIALS

Does Detection of Merkel Cell Polyomavirus in Merkel Cell Carcinoma Provide Prognostic Information?

James A. DeCaprio

Affiliation of author: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Correspondence to: James A. DeCaprio, MD, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Mayer 440, 44 Binney St, Boston, MA 02115 (e-mail: james_decaprio@dfci.harvard.edu).

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Awareness of Merkel cell carcinoma (MCC) is increasing within the scientific and medical communities. MCC is a highly lethal skin cancer: Approximately 30% of all MCC patients die from metastatic disease within 2 years of diagnosis (1). The incidence of this relatively rare skin cancer has increased threefold over the past 20 years (2). Approximately 1500 new cases of MCC were diagnosed in the United States in 2008 (1). Remarkably, a new human polyomavirus (later named Merkel cell polyomavirus [MCPyV]) was discovered last year when viral DNA was found to be integrated into the tumor chromosomal DNA from eight of 10 cases of MCC (3). In one of these cases, DNA . . . [Full Text of this Article]


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J Natl Cancer Inst 2009 101: 901. [Extract] [Full Text] [PDF]