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Journal of the National Cancer Institute Advance Access published online on October 7, 2008
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djn347
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© The Author 2008. Published by Oxford University Press.

EDITORIALS

Modulation of Breast Cancer Risk by Nonsteroidal Anti-inflammatory Drugs

Louise R. Howe, Scott M. Lippman

Affiliations of authors: Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY (LRH); Departments of Thoracic/Head and Neck Medical Oncology and Clinical Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, Houston, TX (SML)

Correspondence to: Scott M. Lippman, MD, Department of Thoracic/Head and Neck Medical Oncology—Unit 432, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030-4009 (e-mail: slippman@mdanderson.org).

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Nonsteroidal anti-inflammatory drugs (NSAIDs) clearly reduce the risk of human colorectal neoplasia in epidemiological and prospective randomized clinical studies of aspirin and nonaspirin NSAIDs, including selective cyclooxygenase-2 (COX-2) inhibitors, or coxibs (1–3). In contrast, the epidemiological and clinical data on NSAIDs in reducing breast cancer risk are not consistent. This inconsistency is likely attributable to contrasting expression patterns of COX-2, a key target of NSAIDs, in breast and colon neoplasia (4,5), and to differing activities of individual NSAIDs (which have varying selectivity for COX-2 vs COX-1), including a potentially selective impact of certain NSAIDs on hormone receptor–positive breast tumors.

In this issue of the Journal, Takkouche et al. (6) report an extensive meta-analysis (involving 38 studies) supporting an inverse association between NSAID use and risk of breast cancer. They found a statistically significant reduction in . . . [Full Text of this Article]

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