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Journal of the National Cancer Institute Advance Access published online on September 9, 2008
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djn269
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© The Author 2008. Published by Oxford University Press.

CORRESPONDENCE

Re: Pharmacogenomic Variation of CYP2D6 and the Choice of Optimal Adjuvant Endocrine Therapy for Postmenopausal Breast Cancer: A Modeling Analysis

David Gurwitz, William Newman

Affiliations of authors: Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv Israel (DG); Department of Medical Genetics, University of Manchester, United Kingdom (WN)

Correspondence to: Dr David Gurwitz, PhD, Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel (e-mail: gurwitz@post.tau.ac.il).

The first 10% of the full text of this article appears below.

The modeling analysis of the Breast International Group 1–98 (BIG1-98) trial presented by Puglia et al. (1) provides an important impetus to further studies of tamoxifen pharmacogenetics. However, it is important to note that their analysis focused solely on the CYP2D6*4 allele. Although CYP2D6*4 is the allele most frequently associated with poor tamoxifen . . . [Full Text of this Article]


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Response to this Correspondence

Response: Re: Pharmacogenomic Variation of CYP2D6 and the Choice of Optimal Adjuvant Endocrine Therapy for Postmenopausal Breast Cancer: A Modeling Analysis
Rinaa S. Punglia, Harold J. Burstein, Eric P. Winer, and Jane C. Weeks
J Natl Cancer Inst 2008 100: 1332-1333. [Extract] [Full Text] [PDF]

Response: Re: Pharmacogenomic Variation of CYP2D6 and the Choice of Optimal Adjuvant Endocrine Therapy for Postmenopausal Breast Cancer: A Modeling Analysis
Daniel F. Hayes, Vered Stearns, James Rae, and David Flockhart
J Natl Cancer Inst 2008 100: 1333-1334. [Extract] [Full Text] [PDF]