Skip Navigation



Journal of the National Cancer Institute Advance Access published online on August 11, 2008
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djn259
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
100/16/1123    most recent
djn259v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Wilt, T. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wilt, T. J.
Related Collections
Right arrowRelated Articles in JNCI
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published by Oxford University Press 2008.

EDITORIALS

SPCG-4: A Needed START to PIVOTal Data to Promote and ProtecT Evidence-Based Prostate Cancer Care

Timothy J. Wilt

Affiliation of author: Minneapolis VA Center for Chronic Disease Outcomes Research, Minneapolis, MN

Correspondence to: Timothy J. Wilt, MD, MPH, Minneapolis VA Center for Chronic Disease Outcomes Research, 1 Veterans Drive (111-0), Minneapolis, MN 55417 (e-mail: tim.wilt@va.gov).

The first 150 words of the full text of this article appear below.

Surgical removal of the prostate for cancer therapy was first performed in 1866 (1), although Young (2) is credited with the first radical surgical procedure in 1904. Prostate cancer deaths were rarely reported in the 1800s, but the relatively high frequency of asymptomatic disease was recognized as early as 1898 (3). Radical prostatectomy has been widely advocated as an effective treatment for localized prostate cancer. However, the only prior randomized trial comparing surgery to watchful waiting (4), begun 40 years ago, failed to demonstrate a survival difference even at 23 years of follow-up. Twenty years ago Whitmore (5) asked these questions regarding the natural history and treatment of prostate cancer: "Is cure necessary in those for whom it is possible and is cure possible in those for whom it is necessary?" Recent systematic reviews have been unable to address Dr . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?

Related Articles in JNCI

Radical Prostatectomy Versus Watchful Waiting in Localized Prostate Cancer: the Scandinavian Prostate Cancer Group-4 Randomized Trial
Anna Bill-Axelson, Lars Holmberg, Frej Filén, Mirja Ruutu, Hans Garmo, Christer Busch, Stig Nordling, Michael Häggman, Swen-Olof Andersson, Stefan Bratell, Anders Spångberg, Juni Palmgren, Hans-Olov Adami, Jan-Erik Johansson, and for the Scandinavian Prostate Cancer Group Study Number 4
J Natl Cancer Inst 2008 100: 1144-1154. [Abstract] [Full Text] [PDF]

IN THIS ISSUE
J Natl Cancer Inst 2008 100: 1119. [Extract] [Full Text] [PDF]

Prostatectomy Improves Outcome of Some Men with Prostate Cancer Over Watchful Waiting
J Natl Cancer Inst 2008 100: 1119. [Extract] [Full Text] [PDF]



This article has been cited by other articles:


Home page
 JAMAHome page
M. G. Sanda and I. D. Kaplan
A 64-Year-Old Man With Low-Risk Prostate Cancer: Review of Prostate Cancer Treatment
JAMA, May 27, 2009; 301(20): 2141 - 2151.
[Abstract] [Full Text] [PDF]

Home page
 JWatch Oncology and HematologyHome page
Radical Prostatectomy vs. Watchful Waiting
Journal Watch Oncology and Hematology, September 16, 2008; 2008(916): 1 - 1.
[Full Text]