Journal of the National Cancer Institute Advance Access published online on April 29, 2008
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djn143
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© Oxford University Press 2008.
NEWS |
End of High-Dose Chemotherapy for High-Risk Breast Cancer Patients?
| The first 10% of the full text of this article appears below. |
High-dose chemotherapy does not improve overall survival in women with high-risk nonmetastatic breast cancer relative to standard chemotherapy, according to a meta-analysis presented last December at the San Antonio Breast Cancer Symposium. This is not the first meta-analysis to show that the approach does not improve breast cancer survival, but it could be the final one; many researchers hope it will end the period in breast cancer care in which opinions seemed to outweigh evidence. However, even with the new data, not everyone is ready to let go of high-dose chemotherapy just yet.
The idea behind the treatment is simple: If standard-dose cytotoxic chemotherapy kills some of the tumor cells, then