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Journal of the National Cancer Institute Advance Access published online on May 13, 2008
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djn129
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© The Author 2008. Published by Oxford University Press.

CORRESPONDENCE

Re: Molecular Basis for Estrogen Receptor {alpha} Deficiency in BRCA1-Linked Breast Cancer

Lara Lusa

Bernard Peissel

Siranoush Manoukian

Edoardo Marchesi

Paolo Radice

Marco A. Pierotti

Manuela Gariboldi

Affiliations of authors: Department of Experimental Oncology (LL, EM, PR, MAP, MG) and Medical Genetics Service (BP, SM) Fondazione IRCCS (Istituti di ricerca e cura a carattere scientifico), Istituto Nazionale dei Tumori, Milano, Italy; Molecular Genetics of Cancer, IFOM Fondazione Istituto FIRC (Fondazione Italiana per la Ricerca sul Cancro) di Oncologia Molecolare, Milano, Italy (LL, EM, PR, MAP, MG)

Correspondence to: Manuela Gariboldi, PhD, Fondazione Istituti di ricerca e cura a carattere scientifico Istituto Nazionale dei Tumori, via G. Venezian 1, 20133 Milano, Italy (e-mail: manuela.gariboldi@istitutotumori.mi.it).

The first 10% of the full text of this article appears below.

We read with great interest the article by Hosey et al. (1), which proposed BRCA1-mediated transcriptional activation of ESR1 in breast cancer cell lines, thus suggesting a direct link between the BRCA1 gene and estrogen response that involves OCT-1. We assessed whether these in vitro results could be clinically confirmed in an independent cohort of primary breast cancer specimens that . . . [Full Text of this Article]

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Response to this Correspondence

Response: Re: Molecular Basis for Estrogen Receptor {alpha} Deficiency in BRCA1-Linked Breast Cancer
Alison M. Hosey, Julia J. Gorski, Jennifer E. Quinn, Wen Y. Chung, Amanda Mccann, and D. Paul Harkin
J Natl Cancer Inst 2008 100: 753-754. [Extract] [Full Text] [PDF]