Journal of the National Cancer Institute Advance Access published online on January 29, 2008
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djm329
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© The Author 2008. Published by Oxford University Press.
EDITORIALS |
Getting Over Testosterone: Postulating a Fresh Start for Etiologic Studies of Prostate Cancer
Affiliations of authors: Departments of Health Policy and Administration (WRC) and Epidemiology (WRR, PAG), UNC School of Public Health, UNC Lineberger Comprehensive Cancer Center (WRC, PAG), UNC Cecil G. Sheps Center for Health Services Research (WRC, PAG), and Department of Medicine, UNC School of Medicine (PAG), University of North Carolina at Chapel Hill, Chapel Hill, NC; North Carolina Comprehensive Cancer Program, Raleigh, North Carolina (WRC)
Correspondence to: Paul A. Godley, MD PhD, CB 7305, 3009 Old Clinic Bldg, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (e-mail: pgodley@med.unc.edu).
| The first 10% of the full text of this article appears below. |
Assessing progress in our understanding of prostate cancer etiology is difficult, although it is certainly clear that we have much to learn. Despite a substantial research investment spanning dozens of years, prostate cancer remains as enigmatic as it is burdensome. We know that increasing age, African American race, residence in a Western nation, and family history are associated with increased prostate cancer risk, although we have yet to identify risk factors that are of substantial magnitude and are amenable to preventive intervention. This is not due to a lack of candidates, including a multitude of environmental, lifestyle, or nutritional factors (1).
Among endogenous factors, elevated androgen
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