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Journal of the National Cancer Institute Advance Access published online on December 11, 2007
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djm263
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Published by Oxford University Press 2007.

EDITORIALS

Genetic and Biologic Evidence that Implicates a Gene in Aggressive Prostate Cancer

Jer-Tsong Hsieh, Jose A. Karam, Wang Min

Affiliations of authors: Department of Urology, University of Texas Southwestern Medical Center at Dallas, TX (JTH, JAK); Interdepartmental Program in Vascular Biology and Transplantation, Department of Pathology, Yale University School of Medicine, New Haven, CT (WM)

Correspondence to: Jer-Tsong Hsieh, PhD, Department of Urology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9110 (e-mail: jt.hsieh@utsouthwestern.edu).

The first 10% of the full text of this article appears below.

In this issue of the Journal, Duggan et al. (1) report that genetic variation, i.e., a single nucleotide polymorphism (SNP) in the DAB2IP gene, may predict the risk of aggressive prostate cancer. The authors explored 60275 SNPs in 498 case patients and 494 control subjects from the Cancer of the Prostate in Sweden study and 737 case patients and 1105 control subjects with European ancestry from Cancer Genetic Markers of Susceptibility (CGEMS) study. Of the 81 SNPs that were associated with aggressive prostate cancer (P<.05 from allele tests), only seven were statistically significant at P less than .01 in both study groups. These . . . [Full Text of this Article]


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