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Journal of the National Cancer Institute Advance Access published online on November 13, 2007
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djm230
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© The Author 2007. Published by Oxford University Press.

EDITORIALS

Estrogen Receptors in BRCA1-Mutant Breast Cancer: Now You See Them, Now You Don’t

V. Craig Jordan

Correspondence to: V. Craig Jordan, OBE, PhD, DSc, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111-2497 (e-mail: v.craig.jordan@fccc.edu).

The first 150 words of the full text of this article appear below.

Estrogen receptor (ER) protein is expressed in estrogen target tissues (1,2). The binding of exogenous estrogen to ER orchestrates many important responses throughout a woman's body to maintain the optimal homeostasis for successful reproduction. Without estrogen, there would be no human race. However, estrogen is also involved in the development and growth of breast and endometrial cancers and, as a result, has recently earned a bad reputation in women's health (3,4).

The measurement of ER expression in breast tumors was originally used to identify which women were likely to respond to endocrine ablation therapy (5). Patients whose tumor expressed no ER were unlikely to respond to endocrine ablative surgery, whereas patients whose tumors had a detectable level of ER had improved chances of responding to ablative surgery (6). However, during the early 1970s ER was recognized as a . . . [Full Text of this Article]


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