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Journal of the National Cancer Institute Advance Access published online on July 10, 2007
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djm048
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© The Author 2007. Published by Oxford University Press.

EDITORIALS

Does Prostate-Specific Antigen Screening Influence the Results of Studies of Tomatoes, Lycopene, and Prostate Cancer Risk?

Edward Giovannucci

Affiliations of author: Department of Nutrition, Harvard School of Public Health, Boston, MA; Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA

Correspondence to: Edward Giovannucci, MD, ScD, Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 (e-mail: egiovann@hsph.harvard.edu).

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In this issue of the Journal, Kavanaugh et al. (1) describe how the U. S. Food and Drug Administration (FDA) evaluated the scientific evidence for proposed qualified health claims for tomatoes and lycopene with respect to the risks of prostate cancer and other types of cancers. After the authors qualitatively reviewed the studies, they concluded that there was "a very low level of comfort that a relationship exists between the consumption of tomatoes and/or tomato sauce and prostate cancer risk." This conclusion is disappointing given that some initial studies of tomato product intake or circulating lycopene levels suggested an association with a reduced risk of prostate cancer, providing some hope for prostate cancer prevention (2–6). However, a number of recent studies, including some (7–9) too recent to be included in the review by Kavanaugh et al. (1), have . . . [Full Text of this Article]


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