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JNCI Journal of the National Cancer Institute 2007 99(6):487; doi:10.1093/jnci/djk097
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© The Author 2007. Published by Oxford University Press.

CORRESPONDENCE

Re: Commonly Studied Single-Nucleotide Polymorphisms and Breast Cancer: Results From the Breast Cancer Association Consortium

Christine B. Ambrosone, Peter G. Shields, Jo L. Freudenheim, Chi-Chen Hong

Affiliations of authors: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (CBA, CCH); Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC (PGS); Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY (CBA, JLF)

Correspondence to: Christine B. Ambrosone, PhD, Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263 (e-mail: christine.ambrosone@roswellpark.org).

The first 10% of the full text of this article appears below.

In a recent pooled analysis of breast cancer data from up to 12 case–control studies from the Breast Cancer Association Consortium (1), five of 16 common single-nucleotide polymorphisms (SNPs) were associated with modest increases in risk. The authors interpreted their findings, with P values ranging from .06 to .0088, as failing to meet a level of statistical significance appropriate to genetic association studies. . . . [Full Text of this Article]


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Response to this Correspondence

Response: Re: Commonly Studied Single-Nucleotide Polymorphisms and Breast Cancer: Results From the Breast Cancer Association Consortium
Paul Pharoah
J Natl Cancer Inst 2007 99: 488-489. [Extract] [Full Text] [PDF]



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