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JNCI Journal of the National Cancer Institute 2007 99(6):424-426; doi:10.1093/jnci/djk123
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© Oxford University Press 2007.

NEWS

TRACING CANCER TO ITS ROOT

Imprinting May Provide Cancer Prevention Tools

Karyn Hede

The first 150 words of the full text of this article appear below.

At a time when sequencing of cancer cell DNA is revealing the tremendous complexity of gene mutations, some researchers are proposing an underlying theme that may precede and could unite all cancers: loss of imprinting (LOI).

Now research from several laboratories is beginning to bear out the hypothesis, indicating that imprinting status may provide a powerful new tool in cancer prevention and early detection. Several companies are rushing to create diagnostic tests for early cancer detection, even as other groups are concentrating on reversing the process to prevent cancer.

Parent-of-origin gene imprinting is part of epigenetics, the study of gene regulation though specific chemical tags called methyl groups that are added to DNA. Without changing the genetic sequence itself, these tags prevent nearby genes from being expressed. The effect is that either the maternal or paternal copy of the gene is expressed, but not both.

The loss-of-imprinting theory suggests that . . . [Full Text of this Article]

Epigenetic Patterns as Biomarkers

The "New Normal"


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