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© Oxford University Press 2007.
NEWS |
SNPs Not Living Up to Promise; Experts Suggest New Approach to Disease ID
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In June 2000, researchers announced to great fanfare that a rough draft of the human genome had been decoded. That achievement—followed up with a completed draft 2 years later—was heralded as the gateway to personalized medicine, a new paradigm for treating patients according to their genetic makeup.
Writing in the New England Journal of Medicine, Francis Collins, M.D., Ph.D., predicted that gene-based primary care would be thriving by 2010. "This knowledge will dramatically accelerate the development of new strategies for the diagnosis, prevention, and treatment of disease," proposed Collins, who directs the National Human Genome Research Institute (NHGRI), in Bethesda, Md., " ... not just for single-gene disorders but [also] for the host of more common, complex diseases [e.g., cancer]."
But today, researchers are substantially downplaying those prospects. "We have more modest, but realistic, expectations," says John Ioannidis, M.D., professor and chair of the University of Ioannina School
An Environmental Perspective
No More Candidate Genes
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