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Journal of the National Cancer Institute Advance Access originally published online on October 30, 2007
JNCI Journal of the National Cancer Institute 2007 99(21):1563-1565; doi:10.1093/jnci/djm211
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Published by Oxford University Press 2007.

EDITORIALS

The "Sunshine Vitamin": Benefits Beyond Bone?

Cindy D. Davis, Johanna T. Dwyer

Affiliations of authors: Nutritional Sciences Research Group, National Cancer Institute, National Institutes of Health, Bethesda, MD (CDD); Office of Dietary Supplements, National Institutes of Health, Bethesda, MD (JTD); School of Medicine and Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (JTD)

Correspondence to: Johanna T. Dwyer, DSc, RD, NIH, Office of Dietary Supplements, 6100 Exec Blvd, MSC7517 Room 3B01, Bethesda, MD 20892 (e-mail: Dwyerj1@od.nih.gov.)

The first 150 words of the full text of this article appear below.

Although vitamin D is best known for its role in strengthening bone and preventing rickets, it is increasingly apparent that it may have beneficial health effects beyond the skeletal system, among them perhaps the prevention of a number of diseases, including cancer (1). These health effects have been the focus of two recent National Institutes of Health–sponsored conferences (2,3) and a number of reviews (4–6).

Could vitamin D also have a role in decreasing total mortality? A meta-analysis by Autier and Gandini (7) of 18 randomized clinical trials of supplemental intakes of vitamin D found a 7% reduction in total mortality from any cause (RR = 0.93, 95% confidence interval [CI] = 0.87 to 0.99). Supplement intakes in those studies generally ranged from 400 to 800 IU/day, which is within the range recommended by the Institute of Medicine' . . . [Full Text of this Article]


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