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© The Author 2007. Published by Oxford University Press.
EDITORIAL |
Prevention of Gastric Cancer: A Miss
Correspondence to: Philip R. Taylor, MD, ScD, Division of Cancer Epidemiology and Genetics, Genetic Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd., Rm. 7006, Bethesda, MD 20892-7236 (e-mail: ptaylor@mail.nih.gov).
| The first 150 words of the full text of this article appear below. |
Despite its declining global incidence and mortality, gastric cancer remains one of the most common cancers in the world, with nearly one million new patients expected to be afflicted with the disease this year. Given the 5-year relative survival rate among gastric cancer patients of only 23% (1), prevention is clearly the preferred strategy to reduce morbidity and mortality from this disease. In addition to secondary prevention approaches, which rely on screening for early detection, primary prevention efforts have focused on chemoprevention, using either nutritional interventions or anti–Helicobacter pylori therapies.
In this issue, Plummer et al. (2) report results of a nutritional intervention for the chemoprevention of gastric premalignancy. This randomized, double-blind, placebo-controlled trial tested the efficacy of daily supplementation for 3 years with a combination of three different nutrients—vitamin C (750 mg/day), vitamin E (600 mg/day), and beta-carotene (18 mg/day)—versus placebo on the regression
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