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Journal of the National Cancer Institute Advance Access originally published online on September 11, 2007
JNCI Journal of the National Cancer Institute 2007 99(18):1355-1356; doi:10.1093/jnci/djm151
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© The Author 2007. Published by Oxford University Press.

EDITORIALS

High-Grade Prostate Cancer in the Prostate Cancer Prevention Trial: Fact or Artifact?

Gerald L. Andriole, Peter A. Humphrey, Robert J. Serfling, Robert L. Grubb

Affiliations of authors: Urologic Surgery (GLA, RLG), Prostate Study Center (GLA), Pathology and Immunology (PAH), and Anatomic and Molecular Pathology (PAH), Washington University School of Medicine, St Louis, MO; Mathematical Sciences, University of Texas at Dallas, Dallas, TX (RJS)

Correspondence to: Gerald L. Andriole, MD, Division of Urologic Surgery, Washington University School of Medicine, 4960 Children's Place, Campus Box 8242, St Louis, MO 63110 (e-mail: andrioleg@wustl.edu).

The first 10% of the full text of this article appears below.

Chemoprevention of prostate cancer is a laudable and desirable goal. One strategy for chemoprevention is androgen deprivation therapy with 5{alpha}-reductase inhibitors, such as finasteride and dutasteride (1,2). The recent landmark Prostate Cancer Prevention Trial (PCPT), which used finasteride, was the first phase III clinical trial of prostate cancer prevention (1). Finasteride is the only intervention that has been shown to reduce the incidence of prostate cancer in a long-term prospective clinical trial (3). However, despite the impressive 24.8% relative reduction . . . [Full Text of this Article]


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