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Journal of the National Cancer Institute Advance Access originally published online on July 10, 2007
JNCI Journal of the National Cancer Institute 2007 99(14):1063; doi:10.1093/jnci/djm063
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© The Author 2007. Published by Oxford University Press.

EDITORIALS

The Origin of Kaposi Sarcoma

Parkash S. Gill

Correspondence to: Parkash S. Gill, MD, Department of Medicine and Pathology, Norris Cancer Hospital and Research Institute, University of Southern California, 1441 Eastlake Ave, Rm 3458, Los Angeles, CA 90033 (e-mail: parkashg@hsc.usc.edu).

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Kaposi sarcoma (KS) is distinct from other cancers in multiple ways. The most remarkable difference is that it first manifiests itself as many distinct tumor lesions at discrete locations. KS is associated with HHV8 infection, whether it develops in the setting of HIV infection and concomitant use of immune-suppressive agents or in older men of Mediterranean descent. Another notable feature of KS is its regression upon withdrawal of immune suppressive agents (or . . . [Full Text of this Article]

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