© The Author 2006. Published by Oxford University Press.
CORRESPONDENCE |
RESPONSE: Re: Tamoxifen for the Prevention of Breast Cancer: Current Status of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
Affiliations of authors: Department of Surgery (BF), Department of Biostatistics (JPC), University of Pittsburgh, Pittsburgh, PA; National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA (BF, JPC)
Correspondence to: Bernard Fisher, MD, 300 Halket St., Suite 350, Pittsburgh, PA 15213 (e-mail: fisherb2@upmc.edu).
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Cuzick et al. contend that it was inappropriate both to announce the results of the National Surgical Adjuvant Breast and Bowel Project (NSABP) prevention trial (P-1) (1,2) and to unblind the participants. They argue that those actions make it difficult to interpret the data from P-1 and that important information has been lost. We disagree.
We question some key points in
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J Natl Cancer Inst 2006 98: 643.
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Y. Shen, J. P. Costantino, and J. Qin Tamoxifen Chemoprevention Treatment and Time to First Diagnosis of Estrogen Receptor-Negative Breast Cancer J Natl Cancer Inst, October 15, 2008; 100(20): 1448 - 1453. [Abstract] [Full Text] [PDF] |
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