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JNCI Journal of the National Cancer Institute 2006 98(9):578-579; doi:10.1093/jnci/djj200
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© Oxford University Press 2006.

NEWS

Experts Wrestle With Problems Developing Biomarkers, Search For New Tests

Nancy J. Nelson

The first 10% of the full text of this article appears below.

Biomarkers have a variety of uses in preclinical development: screening for promising drugs, determining the dosing and scheduling of a drug, predicting the risk of developing disease, predicting a patient's chance of responding to a drug or of having an adverse reaction to a drug, or serving as surrogate endpoints in a trial. And many researchers argue that the proper identification and validation of biomarkers will be important for the future of medicine.

"Only 30% of the patients in clinical trials and patient care have a measurable positive response. The remaining 70% are exposed to risks with no benefit," said Michael Phelps, Ph.D., chair of the Department of Molecular and Medical Pharmacology and director of the Institute for Molecular Medicine at the University of California, Los Angeles. "We have to develop more personalized medicine so that drugs are used by people who stand to . . . [Full Text of this Article]

Suggestions for Improving Cancer Biomarker Development


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