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JNCI Journal of the National Cancer Institute 2006 98(7):428-430; doi:10.1093/jnci/djj127
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© The Author 2006. Published by Oxford University Press.

EDITORIAL

Vitamin D Status and Cancer Incidence and Mortality: Something New Under the Sun

Gary G. Schwartz, William J. Blot

Affiliations of authors: Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC (GGS); International Epidemiology Institute, Rockville, MD, and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN (WJB)

Correspondence to: Gary G. Schwartz, MPH, PhD, Departments of Cancer Biology and Epidemiology, Wake Forest University, School of Medicine, Winston-Salem, NC 27157 (e-mail: gschwart@wfubmc.edu).

The first 150 words of the full text of this article appear below.

In this era of tumor genomics, proteomics, and metabolomics, the idea that fundamental insights about cancer could emerge from observations of the gross characteristics of individual persons (i.e., from classical epidemiology) seems almost anachronistic. Surely the era of discovery of common exposures with broad effects on cancer is over. Or is it?

In this issue of the Journal, Giovannucci et al. (1) report that estimates of vitamin D status derived from the Health Professionals Follow-up Study were associated with statistically significant reductions in total cancer incidence and mortality. Most of the protective effect for vitamin D status comes from an exposure that is common indeed—sunlight. Because many persons think of sunlight only as a cause of cancer (especially melanoma), some perspective may be helpful.

In 1941, Frank Apperly (2), a pathologist, demonstrated an inverse correlation between levels of ultraviolet radiation in North America and mortality . . . [Full Text of this Article]


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