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JNCI Journal of the National Cancer Institute 2006 98(3):219; doi:10.1093/jnci/djj034
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© The Author 2006. Published by Oxford University Press.

CORRESPONDENCE

Central Nervous System Toxicity Induced by Irinotecan

Paul Hamberg, Richard C. J. M. Donders, Daan ten Bokkel Huinink

Affiliations of authors: Departments of Internal Medicine (PH, DBH) and Neurology (RCJMD), Diakonessenhuis Utrecht, Utrecht, The ­Netherlands

Correspondence to: Paul Hamberg, MD, Erasmus MC–Daniel den Hoed Cancer Center, Department of Medical Oncology, P.O. Box 5201, 3008 AE Rotterdam, The Netherlands (e-mail: paulhamberg@yahoo.com).

The first 10% of the full text of this article appears below.

Irinotecan is a semisynthetic derivative of camptothecin that requires bioactivation to form the active metabolite 7-ethyl-10-hydroxycampthothecin (SN-38). The antitumor activity SN-38 is mediated through its inhibition of topoisomerase I. Irinotecan is used mainly to treat patients with disseminated colorectal carcinoma (1).

A 46-year-old man who was diagnosed with a sigmoid carcinoma and liver metastasis . . . [Full Text of this Article]


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