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JNCI Journal of the National Cancer Institute 2006 98(3):154-155; doi:10.1093/jnci/djj038
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© The Author 2006. Published by Oxford University Press.

EDITORIAL

Methylation of Stat1 Promoter Can Contribute to Squamous Cell Carcinogenesis

Heehyoung Lee, Hua Yu

Affiliation of authors: Division of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute of City of Hope National Medical Center, Duarte, CA

Correspondence to: Hua Yu, PhD, Division of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute of City of Hope National Medical Center, Duarte, CA 91010 (e-mail: hyu@coh.org).

The first 10% of the full text of this article appears below.

One of the most recently recognized signaling pathways that regulate tumor cell proliferation and survival involves signal transducers and activators of transcription (STAT) proteins. The STAT family of proteins has seven known members: Stat1, 2, 3, 4, 5A, 5B, and 6. Interestingly, it has become evident that different STAT proteins can serve either tumor suppressing or oncogenic roles. Stat1, for example, functions as a tumor suppressor in several capacities (1–5), whereas Stat3 and to a lesser extent, Stat5, play a critical role in malignant progression at multiple levels (6. . . [Full Text of this Article]


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