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JNCI Journal of the National Cancer Institute 2006 98(10):718-720; doi:10.1093/jnci/djj203
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© The Author 2006. Published by Oxford University Press.

CORRESPONDENCE

RESPONSE: Re: Effect of {gamma}-Linolenic Acid on the Transcriptional Activity of the Her-2/neu (erbB-2) Oncogene

Javier A. Menendez, Ruth Lupu

Affiliations of authors: Fundació d'Investigació Biomèdica de Girona Dr. Josep Trueta and Institut Catalá d'Oncología de Girona-Hospital Universitari de Girona Dr. Josep Trueta, Girona, Catalonia, Spain (JAM); Department of Medicine, Evanston Northwestern Healthcare Research Institute, Evanston, IL, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, and Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL (RL)

Correspondence to: Ruth Lupu, PhD, Evanston Northwestern Healthcare Research Institute, Department of Medicine, 1001 University Place, Evanston, IL 60201 (e-mail: r-lupu@northwestern.edu).

The first 10% of the full text of this article appears below.

We welcome the correspondence by Dr. Das on our recent report that the {omega}-6 fatty acid (FA) {gamma}-linolenic acid (GLA; 18:3n-6) transcriptionally suppresses the Her-2/neu oncogene (1). Although his molecular explanation for the synergism between GLA and trastuzumab is conceptually correct, it is unlikely that binding of GLA and/or its peroxidized products to DNA could explain this interaction.

Specifically, we do not agree with Das's suggestion that a general mechanism involving the generation of lipoperoxides probably . . . [Full Text of this Article]


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Related Correspondence

Re: Effect of {gamma}-Linolenic Acid on the Transcriptional Activity of the Her-2/neu (erbB-2) Oncogene
Undurti N. Das
J Natl Cancer Inst 2006 98: 718. [Extract] [Full Text] [PDF]