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JNCI Journal of the National Cancer Institute 2006 98(10):660-661; doi:10.1093/jnci/djj205
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© The Author 2006. Published by Oxford University Press.

EDITORIAL

Caring for Older Women With Breast Cancer: Can Observational Research Fill the Clinical Trial Gap?

Bruce E. Hillner, Jeanne Mandelblatt

Affiliations of authors: Virginia Commonwealth University, Richmond, VA (BEH); Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC (JM)

Correspondence to: Bruce E. Hillner, MD, Virginia Commonwealth University and Massey Cancer Center, 1101 East Marshall St., Sanger Hall Rm. 7-013, Richmond, VA 23298-0170 (e-mail: hillner@vcu.edu).

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Women aged 65 years or older (herein referred to as "older women") constitute one-half of new breast cancer patients each year (1), and the absolute number of breast cancer cases will double by 2030, with the graying of America (2). Despite their growing numbers, guidelines for appropriate treatment of these older women are limited by the lack of clinical trial data that are specific to this age group, uncertainty about balancing treatment toxicity and benefits, the potential for therapy to amplify preexisting medical conditions, and competing noncancer . . . [Full Text of this Article]


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