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JNCI Journal of the National Cancer Institute 2005 97(7):467; doi:10.1093/jnci/97.7.467
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© 2005 Oxford University Press

IN THIS ISSUE

The first 10% of the full text of this article appears below.

Effect of Antioxidant Vitamins on Second Primary Tumors

Epidemiologic studies have shown an association between low intake of antioxidant vitamins and increased cancer risk, although randomized trials have been equivocal. In this issue (p. 481), Bairati et al. report the results of a randomized trial to investigate the effect of supplementation with {alpha}-tocopherol and {beta}-carotene on risk of second primary cancers in patients with head and neck cancer. Supplementation began on the first day of radiation therapy and continued for 3 years after radiation therapy ended. (The use of {beta}-carotene was discontinued partway through the trial, after which . . . [Full Text of this Article]

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