© 2005 Oxford University Press
EDITORIAL |
Sometimes a Great Notion—An Assessment of Neoadjuvant Systemic Therapy for Breast Cancer
Affiliations of authors: Johns Hopkins Kimmel Cancer Center, Baltimore, MD (NED); Fox Chase Cancer Center, Philadelphia, PA (MM)
Correspondence to: Nancy E. Davidson, MD, Johns Hopkins Kimmel Cancer Center, 1650 Orleans St., Rm. 409, Baltimore, MD 21231 (e-mail: davidna@jhmi.edu).
| The first 150 words of the full text of this article appear below. |
Sometimes I live in the country,Sometimes I live in the town,
Sometimes I get a great notion...
From the song "Good Night, Irene"By Huddie Ledbetter and John Lomax as adapted by Ken Kesey
The use of neoadjuvant (aka, preoperative or primary) systemic therapy for the management of operable breast cancer has been widely heralded as the future of breast cancer treatment. The underlying rationale consists of several important observations including the success of this strategy for locally advanced breast cancer, the utility of the approach to permit organ preservation in other tumor types, and a compelling preclinical literature suggesting that preoperative administration of chemotherapy is associated with improved survival in a rodent breast cancer model. Enthusiasm has also been engendered by the belief that preoperative therapy would improve clinical outcomes, enhance the likelihood of breast conservation, and facilitate prediction of treatment response, thereby leading to individualization of therapy
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