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JNCI Journal of the National Cancer Institute 2005 97(13):1008-1011; doi:10.1093/jnci/dji177
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© 2005 Oxford University Press

BRIEF COMMUNICATION

Human Herpesvirus 8 DNA in Serum During Seroconversion in Allogeneic Bone Marrow Transplant Recipients

Giuseppe Gentile, Angela Capobianchi, Antonio Volpi, Giorgio Palù, Francesca Pica, Arianna Calistri, Maria Angela Biasolo, Pietro Martino

Affiliations of authors: Department of Cellular Biotechnology and Hematology, Univ. "La Sapienza," Rome, Italy (GG, AC, PM); Department of Public Health, Univ. "Tor Vergata," Rome, Italy (AV, FP); Department of Histology, Microbiology, and Medical Biotechnology, Univ. Padova, Padova, Italy (GP, AC, MAB)

Correspondence to: Giuseppe Gentile, MD, Department of Cellular Biotechnology and Hematology, University "La Sapienza," Via Benevento 6, 00161 Rome, Italy (e-mail: gentile{at}bce.uniroma1.it).

To determine the prevalence of human herpesvirus 8 (HHV-8) infection, the rate of HHV-8 seroconversion, and the presence of serum HHV-8 DNA after bone marrow transplantation (BMT), we evaluated sera from 187 Italian BMT donor–recipient pairs. Antibodies to lytic and latent HHV-8 antigens were detected by immunofluorescence. Sera of donor–recipient pairs who seroconverted were examined by real-time polymerase chain reaction (RT-PCR). Before BMT, 24 (13%) of 187 donors and 20 (11%) of 187 recipients were seropositive; after BMT, 28 (15%) of 187 recipients were seropositive. Seroconversion occurred in 19 (11%) of 167 recipients seronegative at baseline: 14 (9%) from 149 seronegative donors and five (28%) from 18 seropositive donors (relative risk of seroconversion with BMT from a seropositive donor = 2.96, 95% confidence interval = 1.21 to 7.25; P = .02, two-sided Fisher's exact test). One donor and two recipients who seroconverted after BMT were positive for HHV-8 by RT-PCR. No HHV-8–related complications were observed after a median follow-up of 6 years. BMT-associated HHV-8 seroconversion is relatively common in seronegative recipients from seropositive donor, but factors other than BMT may also contribute to seroconversion.


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