© 2005 Oxford University Press
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Rescuing COX-2 Inhibitors From the Waste Bin
Affiliations of authors: Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy (AA); Università degli studi dell'Insubria, Varese, Italy (DMN)
Correspondence to: Adriana Albini, Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi 10, 16132, Genova, Italy (e-mail: adriana.albini@istge.it).
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COX-2 inhibition has been a main target for new nonsteroidal anti-inflammatory drug (NSAID) development. The effectiveness of two COX-2specific drugs, Vioxx (rofecoxib) from Merck and Celebrex (celecoxib) from Pfizer, in chronic inflammatory diseases such as arthritis, was so highly promoted that they were among the most prescribed drugs in the category; experimental studies also showed promise in other diseases, including cancer (1). Both drugs have recently met criticism. Vioxx was voluntarily pulled off
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