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JNCI Journal of the National Cancer Institute 2005 97(1):1; doi:10.1093/jnci/97.1.1
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© 2005 Oxford University Press

IN THIS ISSUE

In This Issue

The first 10% of the full text of this article appears below.

Antidepressant Use and Tamoxifen Metabolism

The efficacy of tamoxifen treatment for breast cancer varies widely among women. The drug is metabolized by several cytochrome P450 (CYP) enzymes, including the CYP2D6 isoform. Some selective serotonin reuptake inhibitors (SSRIs), which are commonly prescribed to treat hot flashes in women who take tamoxifen, are known to inhibit CYP2D6. Jin et al. (p. 30) examined the effects of concomitant SSRI use and CYP2D6 genotypes on plasma concentrations of tamoxifen and its metabolites in women who were undergoing tamoxifen therapy for breast cancer. After 4 months of tamoxifen therapy, women with a CYP2D6 homozygous variant . . . [Full Text of this Article]

CRBP-I Function in Breast Epithelium

VEGFR-3 and New Lymphatic Growth

Zinc Deficiency and Upper Aerodigestive Tract Cancer

Progesterone Receptor Gene and Ovarian Cancer Risk

Bone Turnover Markers and Skeletal Complications


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