© 2004 by Oxford University Press
© 2004 Oxford University Press
EDITORIALS |
Angiogenesis and c-Jun
Correspondence to: Judah Folkman, MD, Children's Hospital, New Research Bldg. 12.129, 300 Longwood Ave., Boston, MA 02115 (e-mail: judah.folkman@childrens.harvard.edu)
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A new pathway for tumor angiogenesis, and possibly for other forms of pathologic angiogenesis, is reported in this issue of the Journal by Zhang et al. (1). They showed that when expression of the basic region-leucine zipper protein c-Jun was suppressed in human endothelial cells by transfection with a DNAzyme targeting the c-Jun mRNA, the cells could no longer form new