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JNCI Journal of the National Cancer Institute 2004 96(5):407-410; doi:10.1093/jnci/djh042
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© 2004 Oxford University Press

BRIEF COMMUNICATION

Loss of Insulin-Like Growth Factor-II Imprinting and the Presence of Screen-Detected Colorectal Adenomas in Women

Karen Woodson, Andrew Flood, Lisa Green, Joseph A. Tangrea, Jeffrey Hanson, Brooks Cash, Arthur Schatzkin, Phillip Schoenfeld

Affiliations of authors: Cancer Prevention Studies Branch (KW, LG, JAT, JH) and Division of Cancer Epidemiology and Genetics (AS), National Cancer Institute, National Institutes of Health, Bethesda, MD; Division of Epidemiology, University of Minnesota, Minneapolis (AF); National Naval Medical Center, Bethesda (BC); Division of Gastroenterology, University of Michigan School of Medicine, and Center for Excellence in Health Outcomes Research, Veterans Affairs Medical Center, Ann Arbor, MI (PS).

Correspondence to: Karen Woodson, PhD, MPH, Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 6116 Executive Blvd., Suite 705, MSC 8314, Bethesda, MD 20892 (e-mail: kw114v{at}nih.gov)

Loss of imprinting (LOI) of insulin-like growth factor-II (IGF-II) may be an inherited epigenetic trait that is polymorphic in the population, and its presence may predispose an individual to the development of colorectal cancer. We evaluated the association between LOI of IGF-II in normal colonic mucosal samples and adenomas in women participating in a colonoscopy screening study. Among 40 participants, 11 (27.5%) had LOI of IGF-II in their normal colonic mucosal tissue. After adjusting for body mass index and family history of colorectal cancer, LOI status was associated with a fivefold increased risk of adenoma formation (odds ratio = 5.2, 95% confidence interval = 1.0 to 26.7). On average, IGF-II expression was more than threefold higher among women with LOI of IGF-II than among women with normal imprinting status. Our findings support the hypothesis that LOI of IGF-II is an epigenetic trait polymorphic in the population and suggest that LOI of IGF-II may play a role in colorectal cancer. These findings are intriguing and need to be confirmed in larger studies.


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