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JNCI Journal of the National Cancer Institute 2004 96(3):239-240; doi:10.1093/jnci/djh045
© 2004 by Oxford University Press
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© 2004 Oxford University Press

CORRESPONDENCE

Re: Zinc Supplement Use and Risk of Prostate Cancer

Leslie C. Costello, Renty B. Franklin, Pei Feng, Ming Tan

Affiliations of authors: Department of Biomedical Sciences, Dental School (LCC, RBF, PF), and Greenebaum Cancer Center (MT), University of Maryland, Baltimore, MD.

Correspondence to: Leslie Costello, PhD, Deartment of Biomedical Sciences, Dental School, University of Maryland, Baltimore, 666 W. Baltimore St., Baltimore, MD 21201 (e-mail: lcc001@dental.umaryland.edu)

The first 10% of the full text of this article appears below.

Leitzmann et al. (1) reported that the use of zinc supplements in high amounts (i.e., >100 mg/day) or for a prolonged time (i.e., >=10 years) was associated with an increased risk of developing advanced prostate cancer. Several issues concerning their study need to be addressed. First, the Ptrend (i.e., <.003) that was reported tested whether the relative risk of advanced prostate cancer was the same among the four dose groups and the nonusers. However, no P values were reported . . . [Full Text of this Article]


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Correspondence about this Article

RESPONSE: Re: Zinc Supplement Use and Risk of Prostate Cancer
Michael F. Leitzmann and Edward Giovannucci
J Natl Cancer Inst 2004 96: 240-241. [Extract] [Full Text] [PDF]