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JNCI Journal of the National Cancer Institute 2004 96(23):1731-1733; doi:10.1093/jnci/djh345
© 2004 by Oxford University Press
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© 2004 Oxford University Press

EDITORIAL

Defining the Role of Raloxifene for the Prevention of Breast Cancer

Mamta Kalidas, Susan Hilsenbeck, Powel Brown

Affiliation of authors: Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030

Correspondence to: Powel Brown, MD, PhD, Breast Center, Baylor College of Medicine, MS 600, One Baylor Plaza, Houston, TX 77030 (e-mail: pbrown@breastcenter.tmc.edu)

The first 150 words of the full text of this article appear below.

Over the last 5 years, the results of several breast cancer prevention trials have demonstrated the usefulness of anti-estrogen selective estrogen receptor modulators (SERMs) for the prevention of breast cancer. The National Surgical Adjuvant Breast and Bowel Project (NSABP) P-1 breast cancer prevention trial was the first trial to show a major benefit of a SERM: The anti-estrogen SERM tamoxifen reduced the risk of breast cancer in women who were at high risk of the disease by 49% (1). The results of several other breast cancer prevention trials confirmed the cancer-preventive benefit of tamoxifen [reviewed in Cuzick et al. (2)], although the magnitudes of benefit reported in these other trials were lower than that reported by the P-1 trial. Together, these results provide strong support for the use of tamoxifen to reduce the risk of breast cancer in women at high risk of this . . . [Full Text of this Article]


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