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JNCI Journal of the National Cancer Institute 2004 96(16):1192-1193; doi:10.1093/jnci/djh262
© 2004 by Oxford University Press
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© 2004 Oxford University Press

EDITORIAL

The Conundrum Posed by Cellular Heterogeneity in Analysis of Human Neuroblastoma

Robert A. Ross, Barbara A. Spengler

Affiliation of authors: Laboratory of Neurobiology, Department of Biological Sciences, Fordham University, Bronx, NY

Correspondence to: Robert A. Ross, PhD, Laboratory of Neurobiology, LH 200, Department of Biological Sciences, Fordham University, 441 E. Fordham Rd., Bronx, NY 10458 (e-mail: rross@fordham.edu)

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Examining the methylation patterns of gene promoters has become a powerful tool in the effort to identify and distinguish different tumor subtypes (1,2). Typically associated with tumor suppressor genes, epigenetic silencing of gene expression has been seen in several different cancers. Aberrant hypermethylation has been recorded for genes that function in various aspects of cancer biology, including cell cycle regulation, tumor suppression, apoptosis, and metastasis. The article by Alaminos et al. (3) in this issue is a clear extension of this previous research.

DNA methylation silences gene expression through the addition of methyl groups to cytosine residues of CpG-rich islands present in the promoter region of genes. Whereas housekeeping genes possess CpG regions that are typically unmethylated and therefore transcriptionally active . . . [Full Text of this Article]


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