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JNCI Journal of the National Cancer Institute 2004 96(15):1185-1186; doi:10.1093/jnci/djh237
© 2004 by Oxford University Press
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© 2004 Oxford University Press

CORRESPONDENCE

RESPONSE: Re: BRCA1 and BRCA2 Founder Mutations and the Risk of Colorectal Cancer

Bethany L. Niell, Gad Rennert, Joseph D. Bonner, Stephen B. Gruber

Affiliations of authors: Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor (BLN, JDB, SBG); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor (BLN, SBG); Department of Human Genetics, University of Michigan Medical School, Ann Arbor (SBG); Department of Community Medicine and Epidemiology, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel (GR); CHS National Cancer Control Center, Haifa, Israel (GR)

Correspondence to: Stephen B. Gruber, MD, PhD, MPH, Division of Molecular Medicine and Genetics, 4301 MSRB III, Box 0638, 1150 W. Medical Center Dr., University of Michigan, Ann Arbor, MI 48109-0638 (e-mail: sgruber@umich.edu)

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BRCA1 and/or BRCA2 (BRCA1/2) mutations induce alterations in DNA repair pathways, thereby forcing cells to use more error-prone repair pathways such as nonhomologous end-joining and/or single-strand annealing rather than recombination between homologous DNA sequences (1). In conjunction with these recognized effects on DNA integrity, Friedenson notes that the point estimates of the odds ratios (ORs) for BRCA1/2 carriers from our case–control study of colorectal cancer were slightly higher for those younger than 65 years than for . . . [Full Text of this Article]


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Related Correspondence

Re: BRCA1 and BRCA2 Founder Mutations and the Risk of Colorectal Cancer
Bernard Friedenson
J Natl Cancer Inst 2004 96: 1184-1185. [Extract] [Full Text] [PDF]