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© 2004 Oxford University Press
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Familial Clustering of Hodgkin Lymphoma and Multiple Sclerosis
Affiliations of authors: Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark (HH, KR, NMN, LM, MM); National Institute of Public Health, Copenhagen (SR); The Danish Multiple Sclerosis Registry, Copenhagen (SR, NKH); Department of Neurology, Aarhus University Hospital in Aalborg, Aalborg, Denmark (NKH); Department of Cancer Prevention and Documentation, Danish Cancer Society, Copenhagen (HHS).
Correspondence to: Henrik Hjalgrim, MD, Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark (e-mail: hhj{at}ssi.dk)
Background: Epidemiologic similarities between Hodgkin lymphoma in young adults (i.e., between 15 and 44 years old) and multiple sclerosis have led to the suggestion that these diseases may have related etiologies. Previous investigations have not supported this hypothesis, but the negative results could have been caused by methodologic problems. We therefore assessed the risk of developing Hodgkin lymphoma for patients with multiple sclerosis and for their families and the risk of developing multiple sclerosis for patients with Hodgkin lymphoma and for their families. Methods: We identified 11 790 patients with multiple sclerosis and 19 599 of their first-degree relatives in Danish population-based registers and followed them for the occurrence of Hodgkin lymphoma. Analogously, we identified 4381 patients with Hodgkin lymphoma and 7388 of their first-degree relatives and followed them for the occurrence of multiple sclerosis. The relative risks (RRs) of Hodgkin lymphoma and multiple sclerosis were expressed as standardized incidence ratios (i.e., the ratio between observed and expected numbers of outcomes based on age, sex, and period-specific incidence rates). All statistical tests were two-sided. Results: Overall, six cases of Hodgkin lymphoma were identified in patients with multiple sclerosis (RR for Hodgkin lymphoma = 1.40, 95% confidence interval [CI] = 0.63 to 3.12), two of which occurred in young adults (RR = 1.59, 95% CI = 0.40 to 6.37). The risk of young-adult-onset Hodgkin lymphoma was statistically significantly increased in the first-degree relatives of patients with multiple sclerosis (RR = 1.93, 95% CI = 1.01 to 3.71; n = 9 such lymphomas). Two cases of multiple sclerosis were identified among young adult patients with Hodgkin lymphoma (RR for multiple sclerosis = 0.82, 95% CI = 0.20 to 3.27), and the risk for multiple sclerosis was statistically significantly increased in their first-degree relatives (RR = 2.76, 95% CI = 1.44 to 5.31; n = 9 such multiple sclerosis cases). Conclusion: The observed familial clustering of multiple sclerosis and young-adult-onset Hodgkin lymphoma is consistent with the hypothesis that the two conditions share environmental and/or constitutional etiologies.
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Correspondence about this Article
- Re: Familial Clustering of Hodgkin Lymphoma and Multiple Sclerosis
- Ola Landgren, Kimberly F. Kerstann, Gloria Gridley, Lene Mellemkjaer, Kari Hemminki, Martha S. Linet, and Lynn R. Goldin
J Natl Cancer Inst 2005 97: 543-544.[Extract] [Full Text] [PDF]
- RESPONSE: Re: Familial Clustering of Hodgkin Lymphoma and Multiple Sclerosis
- Henrik Hjalgrim, Klaus Rostgaard, Nete Munk Nielsen, Nils Koch-Henriksen, Lars Munksgaard, Hans H. Storm, and Mads Melbye
J Natl Cancer Inst 2005 97: 544-545.[Extract] [Full Text] [PDF]
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H. Hjalgrim, K. Rostgaard, N. M. Nielsen, N. Koch-Henriksen, L. Munksgaard, H. H. Storm, and M. Melbye RESPONSE: Re: Familial Clustering of Hodgkin Lymphoma and Multiple Sclerosis J Natl Cancer Inst, April 6, 2005; 97(7): 544 - 545. [Full Text] [PDF]
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