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JNCI Journal of the National Cancer Institute 2004 96(1):38-45; doi:10.1093/jnci/djh003
© 2004 by Oxford University Press
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© 2004 Oxford University Press

ARTICLE

Consolidation Therapy With Autologous Bone Marrow Transplantation in Adults With Acute Myeloid Leukemia: A Meta-analysis

Paul C. Nathan, Lillian Sung, Michael Crump, Joseph Beyene

Affiliations of authors: Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children (PCN, LS), Department of Medicine, Princess Margaret Hospital, University Health Network (MC), Department of Health Policy Management and Evaluation (LS), Department of Public Health Sciences (JB), The University of Toronto, Toronto, Ontario, Canada; Program in Population Health Sciences, The Hospital for Sick Children, Toronto (LS, JB).

Correspondence to: Lillian Sung, MD, FRCPC, The Hospital for Sick Children, Division of Haematology/Oncology, 555 University Ave., Toronto, Ontario, M5G 1X8, Canada (e-mail: lillian.sung{at}sickkids.ca)

Background: The optimal consolidation therapy for adults who are in first remission of acute myeloid leukemia after induction chemotherapy and who do not have a histocompatible donor is poorly established. We conducted a meta-analysis to compare the efficacy of autologous bone marrow transplantation with that of non-myeloablative chemotherapy alone (or no further treatment). Methods: Eligible studies were identified by searching electronic databases and by examining the reference lists of relevant studies and review articles. Eligible studies were those that prospectively enrolled adults with acute myeloid leukemia and randomly assigned patients who were in first remission and who did not have a matched sibling donor to one of the two consolidation therapies. Two reviewers independently assessed all studies for relevance and validity. We used a fixed-effects model to calculate the ratio of probabilities for disease-free and overall survival at 48 months or at the nearest recorded assessment point for each study and for all studies combined. All statistical tests were two-sided. Results: We identified 587 potentially relevant studies, 36 of which were retrieved for detailed evaluation. In the six studies eligible for this meta-analysis, a total of 1044 patients were randomly assigned to receive autologous bone marrow transplantation or non-myeloablative chemotherapy (five studies) or autologous bone marrow transplantation or no further treatment (one study). Compared with patients who received chemotherapy or no further treatment, patients who received autologous bone marrow transplantation had a better disease-free survival (ratio of disease-free survival probabilities = 1.24, 95% confidence interval [CI] = 1.06 to 1.44; P = .006) but a similar overall survival (ratio of overall survival probabilities = 1.01, 95% CI = 0.89 to 1.15; P = .86). Conclusion: Our results do not support the routine use of autologous bone marrow transplantation in adult acute myeloid leukemia patients in first remission.


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Correspondence about this Article

Re: Consolidation Therapy With Autologous Bone Marrow Transplantation in Adults With Acute Myeloid Leukemia: A Meta-analysis
Itai Levi, Itamar Grotto, Ronit Yerushalmi, Isaac Ben-Bassat, and Ofer Shpilberg
J Natl Cancer Inst 2004 96: 1038-1039. [Extract] [Full Text] [PDF]

RESPONSE: Re: Consolidation Therapy With Autologous Bone Marrow Transplantation in Adults With Acute Myeloid Leukemia: A Meta-analysis
Paul C. Nathan, Lillian Sung, Michael Crump, and Joseph Beyene
J Natl Cancer Inst 2004 96: 1039-1040. [Extract] [Full Text] [PDF]



This article has been cited by other articles:


Home page
 JNCI J Natl Cancer InstHome page
I. Levi, I. Grotto, R. Yerushalmi, I. Ben-Bassat, and O. Shpilberg
Re: Consolidation Therapy With Autologous Bone Marrow Transplantation in Adults With Acute Myeloid Leukemia: A Meta-analysis
J Natl Cancer Inst, July 7, 2004; 96(13): 1038 - 1039.
[Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
P. C. Nathan, L. Sung, M. Crump, and J. Beyene
RESPONSE: Re: Consolidation Therapy With Autologous Bone Marrow Transplantation in Adults With Acute Myeloid Leukemia: A Meta-analysis
J Natl Cancer Inst, July 7, 2004; 96(13): 1039 - 1040.
[Full Text] [PDF]


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