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JNCI Journal of the National Cancer Institute 2003 95(22):1657-1659; doi:10.1093/jnci/95.22.1657
© 2003 by Oxford University Press
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© 2003 Oxford University Press

NEWS

Still Waiting on Watchful Waiting: Clinical Trials Test Surveillance

Charles Bankhead

The first 10% of the full text of this article appears below.

Undeterred by initial data that favor immediate surgery over surveillance, U.S. prostate cancer investigators continue to explore the watchful waiting strategy as a viable option for selected patients. The latest findings suggest the effort has yet to stem the tide of anxious patients who are abandoning surveillance in favor of more aggressive treatment.

Between one-third and one-half of patients on surveillance with localized prostate cancer pursue interventions within 5 years, according to several studies reported earlier this year at the annual meeting of the American Urological Association (AUA). In certain subgroups, as many as three-fourths drop out of surveillance within 4 to 5 years.

Rising prostate-specific antigen (PSA) levels appear to be the driving force behind many patients’ decision to seek intervention.

"The men just can’t stand to see their PSA values going up," said Judd Moul, M.D., director of the Department of Defense Center for Prostate Disease . . . [Full Text of this Article]


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