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JNCI Journal of the National Cancer Institute 2003 95(20):1553-1555; doi:10.1093/jnci/djg086
© 2003 by Oxford University Press
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© 2003 Oxford University Press

CORRESPONDENCE

RESPONSE: Re: Cancer Incidence in Denmark Following Exposure to Poliovirus Vaccine Contaminated With Simian Virus 40

Eric A. Engels, Hormuzd A. Katki, Philip S. Rosenberg, Morten Frisch

Affiliations of authors: E. A. Engels, H. A. Katki, P. S. Rosenberg, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD; M. Frisch, Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen, Denmark.

Correspondence to: Eric A. Engels, MD, MPH, Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS 8010, Rockville, MD 20892 (e-mail: engelse@exchange.nih.gov).

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We thank Puntoni et al. for their comments on our recent article (1); however, we disagree that our data demonstrate a relationship between early-life exposure to simian virus 40 (SV40)-contaminated poliovirus vaccine and ependymoma incidence. Puntoni et al. calculated a crude relative risk (RR) of 1.46 (95% confidence interval [CI] = 1.06 to 1.95) comparing the 1955–1961 birth cohort (exposed as infants) with the 1946–1952 birth cohort (exposed as children). However, this comparison is of uncertain relevance, because it contrasts two SV40-exposed cohorts rather than the exposed-as-infants and unexposed cohorts, as we did in our article (1). Furthermore, . . . [Full Text of this Article]


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Correspondence about this Article

Re: Cancer Incidence in Denmark Following Exposure to Poliovirus Vaccine Contaminated With Simian Virus 40
Riccardo Puntoni, Matteo Puntoni, and Marcello Ceppi
J Natl Cancer Inst 2003 95: 1552-1553. [Extract] [Full Text] [PDF]