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JNCI Journal of the National Cancer Institute 2003 95(2):165-168; doi:10.1093/jnci/95.2.165
© 2003 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 95, No. 2, 165-168, January 15, 2003
© 2003 Oxford University Press

BRIEF COMMUNICATION

Retinoic Acid Receptor {beta} and Telomerase Catalytic Subunit Expression in Bronchial Epithelium of Heavy Smokers

Jean-Charles Soria, Xiaochun Xu, Diane D. Liu, J. Jack Lee, Jonathan Kurie, Rodolfo C. Morice, Fadlo Khuri, Li Mao, Waun K. Hong, Reuben Lotan

Affiliation of authors: J.-C. Soria, J. Kurie, F. Khuri, L. Mao, W. K. Hong, R. Lotan, Department of Thoracic/Head and Neck Medical Oncology; X. Xu, Department of Clinical Cancer Prevention; R. C. Morice, Department of Pulmonary Medicine; D. D. Liu and J. J. Lee, Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, TX.

Correspondence to: Reuben Lotan, Ph.D., Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Box 432, 1515 Holcombe Blvd., Houston, TX 77030 (e-mail: rlotan{at}mdanderson.org).

ABSTRACT

Expression of retinoic acid receptor {beta} (RAR{beta}) and telomerase catalytic subunit (human telomerase reverse transcriptase [hTERT]) was analyzed in 285 bronchial biopsy specimens from 53 heavy cigarette smokers and four former smokers by using in situ hybridization. Of the 191 biopsy specimens that were positive for RAR{beta}, 69% expressed hTERT, whereas only 54% of the 94 RAR{beta} negative biopsy specimens expressed hTERT (P = .014). Because hTERT expression in bronchial tissue has been previously associated with increased risk of lung cancer, the association between RAR{beta} and hTERT expression suggests that RAR{beta} expression may be an indicator of increased risk of lung cancer in heavy smokers.


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