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JNCI Journal of the National Cancer Institute 2003 95(15):1109; doi:10.1093/jnci/95.15.1109
© 2003 by Oxford University Press
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© 2003 Oxford University Press

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Studies Show No Clear Advantage to High-Dose Chemotherapy

Use of high-dose adjuvant chemotherapy and autologous stem-cell transplantation does not improve the chances of overall survival for a woman with high-risk breast cancer, according to two large, randomized trials of high-dose chemotherapy. However, the studies indicate that the more aggressive treatment may help reduce the risk of relapse.

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Cadmium Induces Estrogenic Effects in Rats


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