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JNCI Journal of the National Cancer Institute 2003 95(14):1040-1043; doi:10.1093/jnci/95.14.1040
© 2003 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 95, No. 14, 1040-1043, July 16, 2003
© 2003 Oxford University Press

COMMENTARY

Is Positron Emission Tomography an Accurate Non-invasive Alternative to Sentinel Lymph Node Biopsy in Breast Cancer Patients?

Ulrich Guller, Egbert Nitzsche, Holger Moch, Markus Zuber

Affiliations of authors: U. Guller, Dept. of Surgery, University of Basel, Basel, Switzerland and Department of Surgery, Duke University Medical Center, Durham, NC; E. Nitzsche, Department of Radiology, Institute of Nuclear Medicine, University of Basel, Basel, Switzerland; H. Moch, Institute of Pathology, University of Basel, Basel, Switzerland; M. Zuber, Department of Surgery, Kantonsspital Olten, Olten, Switzerland.

Correspondence to: Markus Zuber, M.D., Dept. of Surgery, Kantonsspital Olten, CH-4600 Olten, Switzerland (e-mail: mzuber_ol@spital.ktso.ch).

The first 150 words of the full text of this article appear below.

Breast cancer is the most common malignancy among women, leading to approximately 45 000 deaths per annum in the United States (1). The presence of axillary lymph node metastases has major prognostic implications in breast cancer patients (2,3), and it is an important criterion in determining the need for adjuvant chemotherapy (4). Sentinel lymph node (SLN) biopsy has become routine practice in the surgical treatment of patients with breast cancer because the disease status of the SLNs accurately reflects the status of the remaining axillary lymph nodes (5–7). Hence, patients who present with a negative SLN (no metastases) can be spared from having a more traumatic axillary lymph node dissection (ALND), which has been shown to be associated with substantial short- and long-term sequelae (8,9). Despite the enormous advantages of SLN biopsy over ALND . . . [Full Text of this Article]


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