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JNCI Journal of the National Cancer Institute 2003 95(13):925; doi:10.1093/jnci/95.13.925-b
© 2003 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 95, No. 13, 925, July 2, 2003
© 2003 Oxford University Press

IN THIS ISSUE

The first 10% of the full text of this article appears below.

Bias in Studies of Prophylactic Surgery

Women who carry germline mutations in the breast and ovarian susceptibility genes BRCA1 and BRCA2 have an increased risk of developing breast and/or ovarian cancers. Women are being offered prophylactic surgery as a preventive measure to reduce the risk of cancer. Various studies have suggested that prophylactic surgeries are efficacious in reducing cancer risk. Because of the nature of the studies and the rationale behind the decisions women make to undergo genetic testing and prophylactic surgery, Klaren et al. (p. 941) point out that determination of risk reductions from efficacy . . . [Full Text of this Article]

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