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JNCI Journal of the National Cancer Institute 2003 95(1):72-73; doi:10.1093/jnci/95.1.72
© 2003 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 95, No. 1, 72-73, January 1, 2003
© 2003 Oxford University Press

CORRESPONDENCE

Tumor Location and Detection of K-Ras Mutations in Stool From Colorectal Cancer Patients

Milo Frattini, Debora Balestra, Silvana Pilotti, Lucio Bertario, Marco A. Pierotti

Affiliation of authors: M. Frattini, D. Balestra (Department of Experimental Oncology and Unit of Experimental Molecular Pathology, Department of Pathology), S. Pilotti (Unit of Experimental Molecular Pathology, Department of Pathology), L. Bertario (Preventive and Predictive Medicine Unit), M. A. Pierotti (Department of Experimental Oncology), Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.

Correspondence to: Marco A. Pierotti, Ph.D., Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy (e-mail: marco.pierotti@istitutotumori.mi.it).

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Despite the potential effectiveness of colonoscopy and fecal occult blood tests in reducing colorectal cancer mortality, more specific, noninvasive tests are desirable. In this regard, it is possible to detect specific mutations of several genes in stool samples from colorectal cancer patients. Recently, the feasibility of a multitarget assay has been explored (1,2). Because . . . [Full Text of this Article]


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