© 2002 by Oxford University Press
Journal of the National Cancer Institute, Vol. 94, No. 9, 641-643,
May 1, 2002
© 2002 Oxford University Press
EDITORIAL |
The Influence of Menstrual Cycle Phase on Surgical Treatment of Primary Breast Cancer: Have We Made Any Progress Over the Past 13 Years?
Affiliations of author: G. N. Hortobagyi, Department of Breast Medical Oncology and Nellie B. Connally Chair in Breast Cancer Research, The University of Texas M. D. Anderson Cancer Center, Houston.
Correspondence to: G. N. Hortobagyi, M.D., F.A.C.P., The University of Texas M. D. Anderson Cancer Center, Department of Breast Medical Oncology, 1515 Holcombe Blvd., Box 424, Houston, TX 77030–4009 (e-mail: ghortoba@mdanderson.org).
The development and clinical course of breast cancer is modulated by a variety of endocrine influences. This observation led to the development of endocrine interventions, the first successful modality of targeted anticancer therapy. Today, it is widely recognized that endocrine interventions represent the most effective approaches to reducing the odds of recurrence and death for hormone-responsive primary breast cancer and for patients at risk for developing this disease (1–3). These accomplishments required the work of multiple laboratory-based and clinical investigators, the participation of tens of thousands of patients in prospective randomized trials, and the better part of the past three decades. During this time, a number of hypotheses were tested and, although several were proved with evidence, others were disproved, also with evidence.
In 1989, Hrushesky et al. (4) proposed that the timing of surgical interventions for breast cancer had substantial influence on
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