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JNCI Journal of the National Cancer Institute 2002 94(3):158-159; doi:10.1093/jnci/94.3.158
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 3, 158-159, February 6, 2002
© 2002 Oxford University Press

NEWS

Consortium Piecing Together Role of ATM Gene in Breast Cancer

Elizabeth Finkel

For many women who have a strong family history of breast cancer, knowing whether they have inherited gene mutations that predispose them to the disease is key to their ability to manage their fears of developing cancer.

But for more than half the women in this category, no genetic test is available because their family disease is caused by something other than known BRCA1 or BRCA2 mutations, the primary mutations so far unearthed in severely affected families.

For the past several years, research teams around the world have been scouring the genes of these families with little success. "Our nightmare is that there will be 20 or more genes, each accounting for a small fraction of these families," a scenario that will make it very difficult to isolate these genes by the methods that yielded BRCA1 and BRCA2, said David E. Goldgar, Ph.D., of the International Agency for Research on . . . [Full Text of this Article]


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