© 2002 by Oxford University Press
Journal of the National Cancer Institute, Vol. 94, No. 24, 1832-1836,
December 18, 2002
© 2002 Oxford University Press
COMMENTARY |
New Associations of Human Papillomavirus, Simian Virus 40, and Epstein-Barr Virus with Human Cancer
Affiliations of authors: M. Wong, J. Gruber (Biological Carcinogenesis Branch), J. T. Schiller (Laboratory of Cellular Oncology), National Cancer Institute, Bethesda, MD; J. S. Pagano, N. Raab-Traub, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill; S. S. Tevethia, Department of Microbiology and Immunology, Pennsylvania State University, Hershey.
Correspondence to: May Wong, Ph.D., Biological Carcinogenesis Branch, National Cancer Institute, 6130 Executive Blvd., Suite 5000, Rm. 5010, Bethesda, MD 20892 (e-mail: mw132k@nih.gov).
| The first 150 words of the full text of this article appear below. |
Approximately 15% of all cancers worldwide appear to be associated with viral infections, and several human DNA viruses are now accepted as causative factors of specific malignancies. Human papillomaviruses (HPVs) cause cervical and anogenital cancers (1). Epstein-Barr virus (EBV) causes infectious mononucleosis and is closely associated with Burkitt’s lymphoma, nasopharyngeal carcinoma, and Hodgkin’s disease (2,3). HPV is now associated with oral cancers (4–8), EBV with breast and gastric cancers (9,10), and simian virus 40 (SV40) with human mesothelioma and various brain and bone cancers (11–14). Several associations are not universally accepted, and their validity remains controversial. Consequently, the Biological Carcinogenesis Branch of the Division of Cancer Biology at the National Cancer Institute convened a workshop on March 12–13, 2001, in Bethesda, MD, to assess current knowledge concerning associations of
HPV and Tumors of the Oropharynx
Future HPV Research Areas
SV40 in the Human Population
Detection of SV40 in Human Cancers
Validity of Detection of SV40 in Human Cancers
Research Opportunities
EBV and Human Cancers
Detection of EBV in Breast Cancer
EBV Infection of Epithelial Cells
High-Priority EBV Studies
CONCLUSION
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