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JNCI Journal of the National Cancer Institute 2002 94(23):1732-1733; doi:10.1093/jnci/94.23.1732
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 23, 1732-1733, December 4, 2002
© 2002 Oxford University Press

EDITORIAL

New Agents for Cancer Prevention

Raymond N. DuBois

Affiliation of author: R. N. DuBois, Departments of Medicine and Cancer Biology, The Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.

Correspondence to: Raymond N. DuBois, M.D., Ph.D., Department of Medicine/GI; MCN C-2104, Vanderbilt University Medical Center, 1161 21st Ave. South, Nashville, TN 37232–2279 (e-mail: raymond.dubois@vanderbilt.edu).

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In this issue of the Journal, Zhu et al. (1) report that they have synthesized new compounds that stimulate apoptosis. The synthesis is based on the structure of selective cyclooxygenase-2 (COX-2) inhibitors. This work is a tour-de-force in chemical synthesis but appears to lack some important biochemical and biological data required for definitive conclusions. These compounds are said to lack clinically important cyclooxygenase inhibitory activity; however, the authors present no actual experimental data to support this contention. Unfortunately, the authors incorrectly refer to a news report in Science magazine (2) about a National Institutes of Health-sponsored cancer prevention workshop held a few years ago . . . [Full Text of this Article]


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