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JNCI Journal of the National Cancer Institute 2002 94(20):1581-1582; doi:10.1093/jnci/94.20.1581
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 20, 1581-1582, October 16, 2002
© 2002 Oxford University Press


CORRESPONDENCE

Re: Population-Based Case–Control Study of HER2 Genetic Polymorphism and Breast Cancer Risk

Kelvin Y. K. Chan, Annie N. Y. Cheung, Shea-Ping Yip, Hin-Hin Ko, Tsz-Wan Lai, Ui-Soon Khoo

Affiliations of authors: K. Y. K. Chan, A. N. Y. Cheung, T. W. Lai, U.-S. Khoo Department of Pathology, The University of Hong Kong, Hong Kong; H. H. Ko, Department of Pathology, The University of Hong Kong, and Pacific Bridge Project, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; S. P. Yip, Biomedical Science Section, School of Nursing, The Hong Kong Polytechnic University, Hong Kong.

Correspondence to: Ui-Soon Khoo, F.R.C.Path. (U.K.), Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Rd., Hong Kong (e-mail: uskhoo@pathology.hku.hk).

The first 10% of the full text of this article appears below.

Human epidermal growth factor receptor 2 (HER2) is a proto-oncogene encoding a transmembrane glycoprotein with tyrosine kinase activity. The amplification and overexpression of this gene have been observed in breast and ovarian cancers and are associated with the response of breast cancers to chemotherapy. A single nucleotide polymorphism (SNP) at codon 655 resulting in a valine to isoleucine change (Val655Ile) was reported in the Journal . . . [Full Text of this Article]


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