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JNCI Journal of the National Cancer Institute 2002 94(19):1433-1434; doi:10.1093/jnci/94.19.1433
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 19, 1433-1434, October 2, 2002
© 2002 Oxford University Press


COMMENTARY

Oophorectomy for Breast Cancer: History Revisited

Richard R. Love, John Philips

Affiliation of authors: Department of Medicine, Section of Medical Oncology, University of Wisconsin School of Medicine, Madison.

Correspondence to: Richard R. Love, M.D., M.S., 256 WARF, 610 Walnut St., Madison, WI 53726 (e-mail: rrlove@facstaff.wisc.edu).

The first 10% of the full text of this article appears below.

Oophorectomy for the treatment of breast cancer is like taking aspirin for health: it keeps reappearing as an effective therapy with new twists. However, a closer look at the early history of oophorectomy suggests that perhaps the new twists are not new at all. In fact, a brief chronology of the early history of this intervention reveals facts and personages discrepant with common understandings.

It is important to note that oophorectomy was not first used as a treatment for breast cancer at all. A German surgeon, Alfred Hegar, apparently the first physician to perform the procedure on July 27, 1872, was treating benign disease. Although in his later work he recognized the physiologic effects on organs other than the breast from surgical menopause, he did not publish on the subject until 1878 (1). An American physician, Robert . . . [Full Text of this Article]


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